The Adesso sits in a drawer which is a bit off-center from my main monitor. Not bad, but not ideal. Actually would probably be a really good spot if I was left handed. Wacom would probably be in the same place, at least to charge. But it would be nice to be able to have it on my desk without worrying about cords. Keyboard and mouse are also wireless. Probably my biggest irritation with the Adesso is that the cord is not detachable from the table to make it easier to move.
Biggest one though would be at work. I've got a small Intuos4 on my desk, but Bluetooth would let me walk around while I'm talking to my students.
That, and I'm a bit spoiled by the Intuos4 at work and the Adesso just doesn't feel the same
I've been Googling for most of the morning and most of the reports of lag I'm finding are related to either the initial pairing or are blamed on the Bluetooth on the computer, not on the Wacom.
Also miss the express keys on the intuos. Adesso has something similar, but having the ability to program the keys and have specific settings per application is something I miss. I jump around between Photoshop, Flash, Illustrator, and Blender quite a bit.